A thrombin receptor function for platelet glycoprotein Ib-IX unmasked by cleavage of glycoprotein V

A thrombin receptor function for platelet glycoprotein Ib-IX unmasked by cleavage of glycoprotein V.

Glycoprotein (GP) V is a major substrate cleaved by the protease thrombin during thrombin-induced platelet activation. Previous analysis of platelets from GP V-null mice suggested a role for GP V as a negative modulator of platelet activation by thrombin. We now report the mechanism by which thrombin activates GP V -/- platelets. We show that proteolytically inactive forms of thrombin induce ro...

A new "kid" on the platelet thrombin receptor "block": glycoprotein Ib-IX-V.

I f you cut yourself, your hemostatic system will recruit circulating platelets and plasma fibrinogenyfibrin to staunch the loss of blood. These two arms of hemostasis combine to produce the hemostatic plug, comprised of aggregated platelets and deposited fibrin. ‘‘Plug’’ formation is regulated in terms of time, place, and extent so as to minimize bleeding from injured arteriesyveins, while avo...

Platelet Glycoprotein Ib-IX and Malignancy

Platelet glycoprotein Ib-IX as a regulator of systemic inflammation.

OBJECTIVE The platelet glycoprotein Ib-IX (GP Ib-IX) receptor is a well-characterized adhesion receptor supporting hemostasis and thrombosis via interactions with von Willebrand factor. We examine the GP Ib-IX/von Willebrand factor axis in murine polymicrobial sepsis, as modeled by cecal ligation and puncture (CLP). APPROACH AND RESULTS Genetic absence of the GP Ib-IX ligand, von Willebrand f...

The Glycoprotein Ib-IX-V Complex Is a Platelet Counterreceptor for P-Selectin

We have identified platelet glycoprotein (GP) Ibalpha as a counterreceptor for P-selectin. GP Ibalpha is a component of the GP Ib-IX-V complex, which mediates platelet adhesion to subendothelium at sites of injury. Cells expressing P-selectin adhered to immobilized GP Ibalpha, and GP Ibalpha-expressing cells adhered to and rolled on P-selectin and on histamine-stimulated endothelium in a P-sele...